Job Description

Nimble Therapeutics is embarking on its next phase of growth by building a Drug Discovery team in the Greater Philadelphia area, augmenting the company's discovery capabilities present in the Platform group in Madison, WI. Initially located at B+ Labs at the Cira Center in downtown Philadelphia, the Drug Discovery group will focus on the biological and pharmacological characterization and optimization of therapeutics peptides, in addition to supporting the progression of programs into clinical development. 

We are seeking a Senior Scientist to join our Immunology and Pharmacology group which is focused on developing and running cellular assays to characterize and optimize peptides from our drug discovery programs. This position reports to the Head of Biology.

The ideal candidate will be a team player, an ambitious, accomplished scientist with a strong knowledge of immunology and molecular biology and its application to disease in an industry/biotech setting. They will play a key role on program teams by generating decision-making data on the immunological and pharmacological properties of compounds. They will deploy innovative scientific concepts and approaches and execute experimental plans. We are looking for a scientist with a track record of accomplishments in developing and executing innovative assays and methodologies. The applicant should be a skilled scientist who is innovative and comfortable in a fast-paced, entrepreneurial environment.

Responsibilities

• Identify, evaluate, design, and execute experimental plans for in vivo models to characterize the biological and pharmacological properties of program compounds.
• Work with scientists across different disciplines to design and set up in vitro , in vivo and ex vivo assays support multiple platforms/programs.
• Utilize flow-based technologies and develop novel flow panels to profile immune cells and stromal cells from mouse, rat, NHPs and human samples.
• Study cellular and molecular mechanisms of action using in vitro/in vivo and ex vivo systems.
• Isolate and prepare cells for flow cytometry, ELISA, ELISPOT, and cytokine analysis.
• Participate in designing and running pharmacokinetic, pharmacodynamic, and inflammatory models.
• Analyze various samples using qPCR, MSD, ELISA, ELISPOT and Flow Cytometry.
• Statistical analysis of experimental data from in vitro/in vivo studies. Experience with Flowjo is a plus.
• Maintain detailed and well-organized electronic lab notebook.

Requirements

• MS degree with 5+ years of experience OR PhD with 3+ years of experience in Immunology, Microbiology, Cell and Molecular Biology or related disciplines.
• 2+ years of experience in biotech or pharmaceutical industry working in an immunology laboratory is preferred.
• In vivo experience is required and experience working with rats is preferred.
• Extensive technical and hands-on experience with flow-based characterization of immune cells and cell-based assay development.
• Strong expertise in cellular immunology and T cell biology is preferred.
• Ability to work effectively on multiple projects and collaboratively across different teams with diverse experience.
• Work independently and in collaboration with other team members to dose (PO, IV, ID, SQ, IM, IP) and bleeding (tail nicks, submandibular, intracardiac) of rats is preferred.
• Self-motivated, curious, accomplishes goals with minimal oversight.
• Outstanding written and verbal communication skills, ability to work well with colleagues from diverse backgrounds and cultures.
• Desire to routinely interact with and mentor team members, both in-person and remotely.

Nimble Therapeutics values different perspectives and unique ways of thinking and encourage our team members to bring their “whole self” to work. Candidates from underrepresented backgrounds are especially encouraged to apply.

Nimble Therapeutics is proud to offer a flexible work environment, competitive compensation, and a robust, affordable benefit package that includes health, dental, and vision insurance; 15 days of vacation; unlimited paid sick time; paid parental leave; 13 paid company holidays; life and disability insurance; a robust health and safety program; and more.

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